Tramadol
Description
TODO
Indications
- TODO
Administration Routes
Side Effects
- TODO
Dosage
For acute pain:
- 0.75-1.5 mg/kg IM or IV every 4-6 hours
- Dosage should be adjusted according to pain severity and response
- IV push must be given slowly over 2-3 minutes
For post-operative pain:
- Initial 1.5 mg/kg slow IV push.
- Over the next hour, further doses of 0.75 mg/kg may be given every 10-20 minutes.
- (Up to a total dose of 3.75 mg, including the initial bolus)
- After 1 hour, subsequent doses should be 0.75-1.5 mg/kg every 4-6 hours.
Maximum daily dose should not exceed 6 mg/kg/day.
Available forms
- 10 mg tablet
- 20 mg tablet
- 20 mg extended release tablet
- 50 mg extended release tablet
- 10 mg/mL injection solution
- 20 mg/mL injection solution
Pharmacokinetics
The following table is only an approximation, for single doses. Tramadol has a predominantly linear pharmacokinetic profile within the therapeutic dosage range, partially due to production of active metabolite M1.
| Route | Onset | Peak | t1/2β | Duration of action |
|---|---|---|---|---|
| IV | Seconds | Immediate | 5-6 hours | 4-8 hours |
| IM | 10-20 mins | 45 mins | 4-8 hours | |
| O | 60 mins | 2-3 hours | 6 hours | |
| O (ER) | 2-4 hours | 6-8 hours | 8-10 hours | 10-14 hours |
Oral bioavailability: 75%
Interactions
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Notes
A serum concentration of 100-300 ng/ml is usually effective for analgesia.