Tramadol

Description

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Indications

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Administration Routes

Side Effects

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Dosage

For acute pain:

0.75-1.5 mg/kg IM or IV every 4-6 hours
Dosage should be adjusted according to pain severity and response
IV push must be given slowly over 2-3 minutes

For post-operative pain:

Initial 1.5 mg/kg slow IV push.
Over the next hour, further doses of 0.75 mg/kg may be given every 10-20 minutes.
- (Up to a total dose of 3.75 mg, including the initial bolus)
After 1 hour, subsequent doses should be 0.75-1.5 mg/kg every 4-6 hours.

Maximum daily dose should not exceed 6 mg/kg/day.

Available forms

10 mg tablet
20 mg tablet
20 mg extended release tablet
50 mg extended release tablet
10 mg/mL injection solution
20 mg/mL injection solution

Pharmacokinetics

The following table is only an approximation, for single doses. Tramadol has a predominantly linear pharmacokinetic profile within the therapeutic dosage range, partially due to production of active metabolite M1.

Route	Onset	Peak	t_1/2β	Duration of action
IV	Seconds	Immediate	5-6 hours	4-8 hours
IM	10-20 mins	45 mins		4-8 hours
O	60 mins	2-3 hours		6 hours
O (ER)	2-4 hours	6-8 hours	8-10 hours	10-14 hours

Oral bioavailability: 75%

Interactions

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Notes

A serum concentration of 100-300 ng/ml is usually effective for analgesia.