Byte at 04:32, 28 January 2026

2026-01-28T04:32:56Z

← Older revision		Revision as of 04:32, 28 January 2026
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	== Interactions ==		== Interactions ==

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Byte: Created page with "Category:Medications Category:Benzodiazepines Category:Anxiolytics Category:Anesthesia Medications/Adjuncts == Description == Lorazepam is a benzodiazepine sedative used for reduction of anxiety or as an adjunct for anesthesia. == Indications == * Anxiety disorders (only up to 4 months, to minimize chances of dependency) * Anxiety-related insomnia * Anesthesia premedication to relieve anxiety or induce sedation and amnesia * Status epilepticus * Ra..."

2026-01-28T04:28:17Z

Created page with "Category:Medications Category:Benzodiazepines Category:Anxiolytics Category:Anesthesia Medications/Adjuncts == Description == Lorazepam is a benzodiazepine sedative used for reduction of anxiety or as an adjunct for anesthesia. == Indications == * Anxiety disorders (only up to 4 months, to minimize chances of dependency) * Anxiety-related insomnia * Anesthesia premedication to relieve anxiety or induce sedation and amnesia * Status epilepticus * Ra..."

New page

[[Category:Medications]]
[[Category:Benzodiazepines]]
[[Category:Anxiolytics]]
[[Category:Anesthesia Medications/Adjuncts]]
== Description ==

Lorazepam is a [[benzodiazepine]] sedative used for reduction of anxiety or as an adjunct for anesthesia.

== Indications ==

* Anxiety disorders (only up to 4 months, to minimize chances of dependency)
* Anxiety-related insomnia
* Anesthesia premedication to relieve anxiety or induce sedation and amnesia
* Status epilepticus
* Rapid tranquilization of agitated patients
* Alcohol withdrawal
* Panic disorder
* Delirium
* Chemotherapy-associated nausea
* Psychogenic catatonia

== Administration Routes ==

{{Administration routes|o=y|iv=y|im=y}}

== Side Effects ==

* Local injection site reaction
* Ataxia
* Dizziness
* Respiratory depression
* Paradoxical reaction
* Confusion
* Seizures
* Tachycardia
* Hypotension
* Fainting
* Withdrawal symptoms if abruptly discontinued after long-term use
* Cognitive deficits
* Behavioral changes
* Difficulty speaking clearly
* Constipation

== Dosage ==

For anxiety disorder:

* 30 to 45 μg/kg orally, up to 3 times daily

For insomnia:

* 10 to 30 μg/kg orally at bedtime

Premedication for anesthesia:

* 50 μg/kg IM administered 2 hours before surgery
* or, 45 μg/kg IV administered 15 to 20 minutes before surgery

For status epilepticus:

* 100 μg/kg over at least 1 minute
* dose may be repeated every 5 to 10 minutes as needed
* must be diluted with an equal volume of saline (1:1 dilution)

For agitation / delirium:

* loading dose is 20 to 40 μg/kg IV bolus
* maintenance dosage is either:
** 20 to 60 μg/kg IV bolus every 2 to 6 hours as needed, or infusion of 10 to 100 μg/kg/h

For alcohol withdrawal syndrome:

* dose according to symptoms
* 30 μg/kg oral, IM, or IV every 6 hours as needed for the first 24h
* 15 μg/kg oral, IM, or IV every 6 hours as needed for another 24h

For chemotherapy-associated nausea:

* 15 to 30 μg/kg oral or IV, every 6 hours

For psychogenic catatonia:

* 15 to 30 μg/kg orally, IM, or IV, administered daily
* initial dose can be repeated after 3 hours up to two additional times if the initial dose is ineffective
* continuing treatment can be titrated as necessary for symptoms up to a maximum of 120 μg/kg daily, with treatment continuing for up to 5 days.

== Available forms ==

* 0.1 mg tablet {{Pill icon|tablet}}
* 0.25 mg tablet {{Pill icon|tablet}}
* 0.5 mg tablet {{Pill icon|tablet}}
* 1 mg tablet {{Pill icon|tablet}}
* 1 mg extended-release tablet {{Pill icon|ER}}
* 0.25 mg/mL oral solution {{Pill icon|liquid}}
* 0.5 mg/mL injection solution {{Pill icon|vial}}
* 1 mg/mL injection solution {{Pill icon|vial}}

== Pharmacokinetics ==

{| class="wikitable" style="margin:auto; text-align: center;"
|-
! Route !! Absorption Half-Life !! Onset !! Peak !! Elimination Half-Life !! Duration of action
|-
| IV
| 5 min
| 1-5 mins
| Immediate
|rowspan="3"| 12-18 hrs
|rowspan="2"| 12-24 hrs
|-
| IM || 15-20 mins || 15-30 mins || 60-90 mins
|-
| O || 30 mins || 20-30 mins || 2 hrs || 6-8 hrs
|}

Oral bioavailability: 90%

== Interactions ==

TODO

Lorazepam - Revision history

Byte at 04:32, 28 January 2026